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Articles:
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Preprints
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Saha S, González-Maeso J.
Translation-independent association of mRNAs encoding protomers of the 5-HT2A-mGlu2 receptor complex in living cells.
Translation-independent association of mRNAs encoding protomers of the 5-HT2A-mGlu2 receptor complex in living cells.
Martin-Guerrero SM, Martin-Estebane M, Lara Ordoñez AJ, Canovas M, Martin-Oliva D, González-Maeso J, Cutillas PR, Lopez-Gimenez JF.
Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells.
Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells.
Olivet J^, Choi SG^, Sierra S^, O'Grady TM^, de la Fuente Revenga M, Laval F, Botchkarev VV, Gorgulla C, Coote PW, Blavier J, Geffken EA, Lakhani J, Song K, Yeoh ZC, Hu B, Varca AC, Bruyr J, Ibrahim S, Jivanjee T, Bromley JD, Nyquist SK, Richardson A, Yue H, Wang Y, Calonghi N, Stefan A, Spirohn K, Vertommen D, Baietti MF, Lemmens I, Seo H-S, Dozmorov MG, Willems L, Tavernier J, Das K, Leucci E, Hochkoeppler A, Sun Z-Y J, Calderwood MA, Hao T, Shalek AK*, Hill DE*, Boeszoermenyi A*, Arthanari H*, Buhrlage SJ*, Dhe-Paganon S*, González-Maeso J*, Dequiedt F*, Twizere J-C*, Vidal M*.
Expanding the HDAC druggable landscape beyond enzymatic inhibition
Expanding the HDAC druggable landscape beyond enzymatic inhibition
- ^Equal contribution
- *co-corresponding authors
2024
Gaitonde SA, Avet C, de la Fuente Revenga M, Blondel-Tepaz E, Shahraki A, Morales Pastor A, Talagayev V, Robledo P, Kolb P, Selent J, González-Maeso J, Bouvier M.
Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor
Molecular Psychiatry (Online ahead of print)
Zhu B^, Ainsworth RI^, Wang Z, Liu Z, Sierra S, Deng C, Callado LF, Meana JJ, Wang W*, Lu C*, González-Maeso J*
Antipsychotic-induced epigenomic reorganization in frontal cortex samples from individuals with schizophrenia.
eLife 12:RP92393 (2024)
Takaba R, Ibi D, Yoshida K, Hosomi E, Kawase R, Kitagawa H, Goto H, Achiwa M, Mizutani K, Maede K, González-Maeso J, Hitagaki A, Hiramatsu M.
Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice.
Naunyn-Schmiedeberg's Archives of Pharmacology 397:3523 (2024)
2023
Jaster AM, González-Maeso J.
Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics.
Molecular Psychiatry 28:3595-3612 (2023)
Zhang Q, Ma S, Liu Z, Zhu B, Zhou Z, Li G, Meana JJ, González-Maeso J, Lu C.
Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes.
Nature Communications 14:4672 (2023)
Meana JJ, González-Maeso J.
Serotonin 5-HT2A receptors in schizophrenia: Reflexions on an unfinished story.
European Neuropsychopharmacology 74:89-91 (2023)
Saha S, González-Maeso J.
The crosstalk between 5-HT2AR and mGluR2 in schizophrenia.
Neuropharmacology 230:109489 (2023)
2022
Wolstenholme J, Saunders JM, Smith M, Kang J, Hylemon P, González-Maeso J, Fagan A, Zhao D, Sikaroodi M, Herzog J, Shamsaddani A, Rodriguez M, Su L, Tai Y-L, Zheng J, Cheng B-C, Sartor R, Gillevet P, Zhou H, Bajaj J.
Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice.
Nature Communications 13:6198 (2022)
Saunders JM, Muguruza C, Sierra S, Moreno JL, Callado LF, Meana JJ, Beardsley PM, González-Maeso J.
Glucocorticoid receptor dysregulation underlies 5-HT2A receptor-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model.
Journal of Biological Chemistry 298:102481 (2022)
Jaster AM, Younkin J, Cuddy T, de la Fuente Revenga M, Poklis JL, Dozmorov MG, González-Maeso J.
Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice.
Neuroscience Letters 788:136836 (2022)
de la Fuente Revenga M, Jaster AM, McGinn J, Silva G, Saha S, González-Maeso J.
Tolerance and cross-tolerance among psychedelic and non-psychedelic 5-HT2A receptor agonists in mice.
ACS Chemical Neuroscience 13:2436-2448 (2022)
Meng J, Xu C, Lafon P-A, Roux S, Mathieu M, Zhou R, Scholler P, Blanc E, Becker J.A.J, Le Merrer J, González-Maeso J, Chames P, Liu J, Pin JP, Rondard P.
Optical biosensors of native membrane protein complexes reveal a high proportion of mGlu heterodimers in the brain.
Nature Chemical Biology 18:894-903 (2022)
Jaster AM, Elder H, Marsh SA, de la Fuente Revenga M, Negus SS*, González-Maeso J*
Effects of the 5-HT2A receptor antagonist volinanserin on head-twitch response and intracranial self-stimulation depression induced by different structural classes of psychedelics in rodents.
Psychopharmacology 239:1665-1667 (2022)
Sierra A, Muchhala KH, Jessup DK, Contreras KM, Shah UH, Stevens DL, Jimenez J, Cuno Lavilla XK, de la Fuente Revenga M, Lippold KM, Shen S, Poklis JL,, Qiao LY, Dewey WL, Akbarali HI, Damaj MI, González-Maeso J.
Sex-specific role for serotonin 5-HT2A receptor in modulation of opioid-induced antinociception and reward in mice.
Neuropharmacology 209:108988 (2022)
Jaster AM, González-Maeso J.
An upside-down binding mode to treat psychosis
Nature Neuroscience 25:4-6 (2022)
Jaster AM, de la Fuente Revenga, González-Maeso J.
Molecular targets of psychedelic-induced plasticity
Journal of Neurochemistry 162:(80-88 (2022)
Ferre S, Ciruela F, Dessauer CW, González-Maeso J, Hebert TE, Jockers R, Logothetis DE, Pardo L.
G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs) as targets for drug discovery.
Pharmacology & Therapeutics 231:107977 (2022)
Vohra HZ, Saunders JM^, Jaster AM^, de la Fuente Revenga M, Jimenez J, Fernandez-Teruel A, Wolstenholme JT, Beardsley PM, González-Maeso J.
Sex-specific effects of psychedelics on prepulse inhibition of startle in 129S6/SvEv mice.
Psychopharmacology 239:1649-1664 (2022)
2021
de la Fuente Revenga M, Zhu B^, Guevara CA^, Naler LB, Saunders JM, Zhou Z, Toneatti R, Sierra S, Wolstenholme JT, Beardsley PM, Huntley GW, Lu C*, González-Maeso J*
Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice.
Cell Reports 37:109836 (2021)
Fernandez-Teruel A, Oliveras I, Cañete T, Rio-Alamos C, Tapias-Espinosa C, Sampedro-Viana D, Sanchez-Gonzalez A, Sanna F, Torrubia R, González-Maeso J, Driscoll P, Moron I, Torres C, Aznar S, Tobeña A, Corda MG, Giordi O.
Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia- and addiction-related features: The RHA vs. RLA rats.
Neuroscience & Biobehavioral Reviews 131:597-617 (2021)
Egusquiza I, Munarriz-Cuezva E, Segarra R, González-Maeso J, Callado LF, Meana JJ, Diez-Alarcia R.
Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia.
Pharmacological Reports 73:1136-1146 (2021)
Zhang Y, Kang JD, Zhao D, Ghosh SS, Wang Y, Tai Y, González-Maeso J, Sikaroodi M, Guillevet PM, Lippman R, Hylemon PB, Zhou H, Bajaj J.
Hepatic branch vagotomy modulates the gut-liver-brain axis in murine cirrhosis.
Frontiers in Physiology 12:702646 (2021)
Martin-Guerrero SM, Alonso P, Iglesias A, Cimadevila M, Brea J, Loza MI, Casado P, Martin-Oliva D, Cutillas PR, González-Maeso J*, Lopez-Gimenez JF*.
His452Tyr Polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics.
Biochemical Pharmacology 185:114440 (2021)
Sanchez-Gonzalez A, Thougaard E, Tapias-Espinosa C, Cañete T, Sampedro-Viana D, Saunders JM, Toneatti R, Tobeña A, González-Maeso J, Aznar S, Fernandez-Teruel A.
Increased thin-spine density in frontal cortex pyramidal neurons in a genetic rat model of schizophrenia-relevant features.
European Neuropsychopharmacology 44:79-91 (2021)
de la Fuente Revenga M^*, Shah U^, Nassehi N, Jaster A, Hemanth P, Sierra S, Dukat M, González-Maeso J*.
Psychedelic-like properties of quizapine and its structural analogs in mice.
ACS Chemical Neuroscience 12:831-844 (2021)
2020
Toneatti R, Shin JM, Shah UH, Mayer CR, Saunders JM, Fribourg M, Arsenovic PT, Janssen WG, Sealfon SC, Lopez-Gimenez JF, Benson DL, Conway DE, González-Maeso J.
Interclass GPCR heteromerization affects localization and trafficking
Science Signaling 13, eaaw3122 (2020)
Shah UH, Toneatti R, Gaitonde SA, Shin JM, González-Maeso J.
Site-specific incorporation of genetically encoded photo-crosslinkers locates the heteromeric interface of a GPCR complex in living cells.
Cell Chemical Biology 27:1308-1317 (2020)
Ellaithy A, González-Maeso J, Logothetis DE, Levitz J.
Structure and function of class C G protein-coupled receptors
Trends in Biochemical Sciences 45:1049-1064 (2020)
Saunders JM, Moreno JL, Ibi D, Sikaroodi M, Kang DJ, Muñoz-Moreno R, Dalmet SS, Garcia-Sastre A, Gillevet PM, Dozmorov MG, Bajaj JS, González-Maeso J.
Gut microbiota manipulation during the prepubertal period shapes behavioral abnormalities in a mouse neurodevelopmental disorder model.
Scientific Reports 10:4697 (2020)
Sierra S, Kippold KM, Stevens DL, Poklis JL, Dewey WL, González-Maeso J.
Adjunctive effect of the 5-HT2C receptor agonist lorcaserin on opioid-induced antinociception in mice.
Neuropharmacology 167:107949 (2020)
de la Fuente Revenga M, Vohra HZ, González-Maeso J.
Automated quantification of head-twitch response in mice via ear tag reported coupled with biphasic detection
Journal of Neuroscience Methods 334:108595 (2020)
Osterbog TB, On DM, Oliveras I, Rio-Alamos C, Sanchez-Gonzalez A, Tapias-Espinosa C, Tobeña A, González-Maeso J, Fernandez-Teruel A, Aznar S.
Metabotropic glutamate 2 and dopamine receptor 2 gene expression predict sensorimotor gating response in the genetically heterogeneous NIH-HS rat strain.
Molecular Neurobiology 57:1516-1528 (2020)
Liu R, Kang JD, Balfour Sartor R, Sikaroodi M, Fagan A, Gavis E, Zhou H, Hylemon PB, Herzog JW, Li X, Lippman RH, González-Maeso J, Wade JB, Gosh S, Gurley E, Gillevet PM, Bajaj JS.
Neuroinflammation in murine cirrhosis is dependent on the gut microbiome and is attenuated by fecal transplant.
Hepatology 71:611-626 (2020)
2019
Garcia-Bea A, Miranda-Azpiazu P, Muguruza C, Marmolejo S, Diez-Alarcia R, Gabilondo AM, Callado LF, Morentin B, González-Maeso J, Meana JJ.
Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: selective biased agonism via Gi1-proteins.
European Neuropsychopharmacology 29:1453-1463 (2019)
Ruso-Julve F, Pombero A, Pilar-Cuellar F, Garcia-Diaz N, Garcia-Lopez R, Juncal-Ruiz M, Castro E, Diaz A, Vazquez-Bourgon J, Garcia-Blanco A, Garro-Martinez E, Pisonero H, Estirado A, Ayesa-Arriola R, Lopez-Gimenez JF, Mayor F Jr, Valizan E, Meana JJ, González-Maeso J, Martinez S, Vaque JP, Crespo-Facorro B.
Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK molecular effects of antipsychotics.
Translational Psychiatry 9:306 (2019)
Saunders JM, González-Maeso J, Bajaj JS.
The Toll of hyperammonemia on the Brain
Cellular and Molecular Gastroenterology and Hepatology 8:649-650 (2019)
de la Fuente Revenga M, Shin JM, Vohra HZ, Hideshima KS, Schneck M, Poklis JL, González-Maeso J.
Fully automated head-twitch detection system for the study of 5-HT2A receptor pharmacology in vivo.
Scientific Reports 9:14247 (2019)
Shah UH, González-Maeso J.
Serotonin and glutamate interactions in preclinical schizophrenia models
ACS Chemical Neuroscience 10:3068-3077 (2019)
Bajaj J, Sikaroodi M, Fagan A, Heuman D, Gilles HC, Gavis E, Fuchs M, González-Maeso J, Nizam S, Gillevet P, Wade J.
Post-traumatic stress disorder is associated with altered gut microbiota that modulates cognitive performance in veterans with cirrhosis.
American Journal of Physiology - Gastrointestinal and Liver Physiology 317:G661-G669 (2019).
Shah UH, Gaitonde SA, Moreno JL, Glennon RA, Dukat M, González-Maeso J.
Revised pharmacophore model for 5-HT2A receptor antagonists derived from the atypical antipsychotic agent risperidone.
ACS Chemical Neuroscience 10:2318-2331 (2019)
de la Fuente Revenga M, Ibi D, Cuddy T, Toneatti R, Kurita M, Ijaz MK, Ijaz MK, Miles MF, Wolstenholme JT, González-Maeso J.
Chronic clozapine treatment restrains via HDAC2 the performance of mGlu2 receptor agonism in a rodent model of antipsychotic activity.
Neuropsychopharmacology 44:443-454 (2019)
2018
Hideshima KS, Hojati A, Saunders JM, On DM, de la Fuente Revenga M, Shin JM, Sanchez-Gonzalez A, Dunn CM, Pais AB, Pais AC, Miles MF, Wolstenholme JT, González-Maeso J.
Role of mGlu2 in the 5-HT2A receptor-dependent antipsychotic activity of clozapine in mice.
Psychopharmacology 235:3149-3165 (2018)
Mato S, Pilar-Cuellar F, Valdizán EM, González-Maeso J, Rodríguez-Puertas R, Meana JJ, Salles J, Crespo-Facorro B, Pazos A.
Selective up-regulation of cannabinoid CB1 receptor coupling to Go-proteins in suicide victims with mood disorders.
Biochemical Pharmacology 157:258-265 (2018)
de la Fuente Revenga M, Ibi D, Saunders JM, Cuddy T, Ijaz MK, Toneatti R, Kurita M, Holloway T, Shen L, Seto J, Dozmorov MG, González-Maeso J.
HDAC2-dependent antipsychotic-like effects of chronic treatment with the HDAC inhibitor SAHA in mice.
Neuroscience 388:102-117 (2018)
Ma S, de la Fuente Revenga M, Sun Z, Sun C, Murphy TW, Xie H, González-Maeso J, Chang L.
Cell-type-specific brain methylomes profiled via ultralow-input microfluidics
Nature Biomedical Engineering 2:183-194 (2018)
Mitchell AC, Javidfar B, Pothula V, Ibi D, Shen EY, Peter CJ, Bicks LK, Fehr T, Jiang Y, Brennand KJ, Neve RL, González-Maeso J, Akbarian S.
MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.
Molecular Psychiatry 23:123-132 (2018)
Fomsgaard L, Moreno JL, de la Fuente Revenga M, Brudek T, Adamsen D, Rio-Alamos C, Saunders J, Klein AB, Oliveras I, Cañete T, Blazquez G, Tobeña A, Fernandez-Teruel A, González-Maeso J, Aznar S.
Diferences in 5-HT2A and mGlu2 receptor expression levels and repressive epigenetic modifications at the 5-HT2A promoter region in the Roman Low- (RLA-I) and High (RLA-I) avoidance rat strains.
Molecular Neurobiology 55:1998-2012 (2018)
2017
Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, Garcia-Bea A, Kurita M, Mosley GE, Jiang Y, Christoffel DJ, Callado LF, Russo SJ, Dracheva S, Lopez-Gimenez JF, Ge Y, Escalante CR, Meana JJ, Akbarian S, Huntley GW, González-Maeso J.
Antipsychotic-induced Hdac2 transcription via NF-kB leads to synaptic and cognitive side effects.
Nature Neuroscience 20:1247-1259 (2017)
Fribourg M, Logothetis DE, González-Maeso J, Sealfon SC, Galocha-Iragüen B, Las-Heras Andres F, Brezina V.
Elucidation of molecular kinetic schemes from macroscopic traces using system identification.
PLoS Computational Biology 13(2):e1005376 (2017)
Lopez-Gimenez JF, de la Fuente Revenga M, Ruso-Julve F, Saunders JM, Moreno JL, Crespo-Facorro B, González-Maeso J.
Validation of schizophrenia gene expression profile in a preclinical model of maternal infection during pregnancy.
Schizophrenia Research 189:217-218 (2017)
Oliveras I, Sánchez-González A, Sampedro-Viana D, Piludu MA, Río-Alamos C, Giorgi O, Corda MG, Aznar S, González-Maeso J, Gerbolés C, Blázquez G, Cañete T, Tobeña A, Fernández-Teruel A.
Differential effects of antipsychotic and propsychotic drugs on prepulse inhibition and locomotor activity in Roman high- (RHA) and low-avoidance (RLA) rats.
Psychopharmacology 234:957-975 (2017)
2016
Holloway T, Moreno JL, González-Maeso J.
HSV-mediated transgene expression of chimeric constructs to study behavioral function of GPCR heteromers in mice.
The Journal of Visualized Experiments 113 (2016)
Younkin J, Gaitonde SA, Ellaithy A, Vekariya RH, Baki L, Moreno JL, Shah S, Drossopoulos P, Hideshima KS, Eltit JM, González-Maeso J, Logothetis DE, Dukak M, Glennon RA.
Reformulating a pharmacophore for 5-HT2A serotonin receptor antagonists.
ACS Chemical Neuroscience 7:1292-1299 (2016)
Gaitonde SA, González-Maeso J
Contribution of heteromerization to G protein-coupled receptor function.
Current Opinion in Pharmacology 32:23-31 (2016)
Baki L, Fribourg M, Younkin J, Eltit JM, Moreno JL, Park Gyu, Vysotskaya Z, Narahari A, Sealfon SC, González-Maeso J, Logothetis DE.
Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.
Pflügers Archiv - European Journal of Physiology 468:775-793 (2016)
Moreno JL, Miranda-Azpiazu P, Garcia-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Moron JA, Milligan G, Lopez-Gimenez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J.
Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
Science Signaling 9:ra5 (2016)
2015
Ellaithy A, Younkin J, González-Maeso J*, Logothetis DE*.
Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment.
Trends in Neurosciences 38:506-516 (2015)
Holloway T, González-Maeso J.
Epigenetic mechanisms of serotonin signaling.
ACS Chemical Neuroscience 6:1099-1109 (2015)
Ibi D, González-Maeso J.
Epigenetic signaling in schizophrenia.
Cellular Signalling 27:2131-2136 (2015)
2014
Muguruza C, Miranda-Azpiazu P, Diez-Alarcia R, Morentin B, González-Maeso J, Callado LF, Meana JJ.
Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.
Neuropharmacology 86:311-318 (2014)
Gatch MB, Kozlenkov A, Huan RQ, Yang W, Nguyen JD, González-Maeso J, Rice KC, France CP, Dillon GH, Forster MJ, Schetz JA.
The HIV antiretroviral drug efavirenz has LSD-like properties.
Neuropsychopharmacology 38:2373-2384 (2013)
González-Maeso J.
Family A GPCR heteromers in animal models.
Frontiers in Pharmacology 5:226 (2014)
Hatcher-Solis C, Fribourg M, Spyridaki K, Younkin J, Ellaithy A, Xiang G, Liapakis G, González-Maeso J., Zhang H, Cui M, Logothetis DE. G protein coupled receptor signaling in Xenopus oocytes.
Current Pharmaceutical Biotechnology 15:987-995 (2014)
2013
Kurita M, Moreno JL, Holloway T, Kozlenkov A, Mocci G, Garcia-Bea A, Neve R, Nestler EJ, Russo SJ, González-Maeso J.
Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice.
Molecular Pharmacology 86:1166-1175 (2013)
Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J.
Chronic treatment with LY341495 decreases 5-HT2A binding and hallucinogenic effects of LSD in mice.
Neuroscience Letters 536:69-73 (2013)
Golden SA, Christoffel DJ, Hodes GE, Heshmati M, Magida J, Davis K, Cahill ME, Dias C, Ribeiro E, Ables JL, Kennedy PJ, Robinson AJ, González-Maeso J, Neve RL, Turecki G, Ghose S, Tamminga CA, Russo SJ.
Epigenetic regulation of synaptic remodeling in stress disorders.
Nature Medicine 19:337-344 (2013)
Muguruza C, Moreno JL, Umali A, Callado LF, Meana JJ, González-Maeso J.
Dysregulated 5-HT2A receptor binding in postmortem frontal cortex of schizophrenic subjects.
European Neuropsychopharmacology 23:852-864 (2013)
Holloway T, Moreno JL, Umali A, Rayannavar V, Hodes GE, Russo SJ, González-Maeso J.
Prenatal stress induces schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring: Role of maternal immune system.
Journal of Neuroscience 33:1088-1098 (2013).
Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J.
Long-lasting effects of chronic clozapine on the psychosis-like states induced by LSD in mice.
Psychopharmacology 225:217-226 (2013).
Hanks JB, González-Maeso J.
Animal models of serotonergic psychedelics.
ACS Chemical Neuroscience 4:33-42 (2013)
Moreno JL, González-Maeso J.
Preclinical models of antipsychotic drug action.
The International Journal of Neuropsychopharmacology 16:2131-2144 (2013)
Kurita M, Holloway T, González-Maeso J.
HDAC2 as a new target to improve schizophrenia treatment.
Expert Review of Neurotherapeutics 13:1-3 (2013)
2012
Williams A, Ingram WM, Levine S, Resnik J, Kamel C, Lish JR, Elizalde DI, Janowski SA, Shoker J, Kozlenkov A, González-Maeso J, Gallitano AL.
Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine.
Neuropsychopharmacology 37:2285-2298 (2012)
Kurita M, Holloway T, Garcia-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden S, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J.
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Nature Neuroscience 15:1245-1254 (2012)
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuellar F, Mocci G, Hanks J, Seto J, Callado LF, Milligan G, Sealfon SC, Lopez-Gimenez JF, Meana JJ, Benson DL, González-Maeso J.
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A-mGlu2) receptor heteromerization and its psychoactive behavioral function.
Journal of Biological Chemistry 287:44301-44319 (2012)
González-Maeso J, Sealfon SC.
Functional selectivity in GPCR heterocomplexes.
Mini-Reviews in Medicinal Chemistry 12:851-855 (2012)
2011
Albizu L, Holloway T, González-Maeso J, Sealfon SC.
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors.
Neuropharmacology 61:770-777 (2011)
Moreno JL, Holloway T, Albizu L, Sealfon, SC, González-Maeso J.
Metabotropic glutamate receptor mGlu2 is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonist.
Neuroscience Letters 493:76-79 (2011)
Moreno JL, Kurita M, Holloway T, Lopez J, Cadagan R, Martinez-Sobrido L. Garcia-Sastre A, González-Maeso J.
Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors complex in the adult offspring.
Journal of Neuroscience 31:1863-1872 (2011).
Fribourg M, Moreno, JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerrell AD, Brezina V, Sealfon SC, Filizola M, González-Maeso J*, Logothetis DE*.
Decoding the signaling of a GPCR heteromeric complex reveals the mechanism of action of antipsychotic drugs.
Cell 147:1011-1023 (2011)
González-Maeso J.
GPCR oligomers in pharmacology and signaling.
Molecular Brain 4:20-26 (2011)
2010
Valdizan EM, Diez-Alarcia R, González-Maeso J, Pilar-Cuellar F, Garcia-Sevilla J, Meana JJ, Pazos A.
Alpha2-adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims.
Biological Psychiatry 68:869-872 (2010)
Albizu L, Moreno JL, González-Maeso J, Sealfon SC.
G protein-coupled receptor heterodimers and novel drug targets.
CNS & Neurological Disorders—Drug Targets 9:636-650 (2010)
González-Maeso J. Anxious interactions.
Nature Neuroscience 13:524-526 (2010)
2009
Moreno JL, Sealfon SC, González-Maeso J.
Group II metabotropic glutamate receptors and schizophrenia.
Cellular and Molecular Life Sciences 66:3777-3785 (2009)
González-Maeso J, Sealfon SC. Psychedelics and schizophrenia.
Trends in Neurosciences 32:225-232 (2009)
González-Maeso J, Sealfon SC.
Agonist-signaling trafficking and hallucinogens.
Current Medicinal Chemistry 16:1017-1027 (2009)
2008 and before
González-Maeso J*, Ang R, Yuen T, Chan P, Weisstaub NV, Lopez-Gimenez J, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Meana JJ, Sealfon SC*.
Identification of a glutamate/serotonin receptor complex implicated in psychosis. Nature 452:93-97 (2008)
Sealfon SC, González-Maeso J.
Receptor pair for schizophrenia.
Pediatric Research 64:1 (2008)
González-Maeso J*, Weisstaub NV*, Zhou M, Lira A, Bradley-Moore M, Chan P, Ivic L, Ge Y, Zhou Q, Sealfon SC, and Gingrich JA.
Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior.
Neuron 53:439-452 (2007)
González-Maeso J, Meana JJ.
Heterotrimeric G proteins: Insights into the Neurobiology of Mood Disorders.
Current Neuropharmacology 4:127-138 (2006)
Nair VD, McNaught, KP, González-Maeso J, Sealfon SC, Olanow CW.
p53 Mediates non-transcriptional mediated cell death in dopaminergic cells in response to proteasome inhibition.
Journal of Biological Chemistry 281:39550-39560 (2006)
Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA.
Cortical 5-HT2A receptor signaling specifically modulates anxiety-related behaviors in mice.
Science 313:536-540 (2006)
Chan P, Yuen T, Ruf F, González-Maeso J, Sealfon SC.
Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization.
Nucleic Acid Research 33:e161 (2005)
Chan P, González-Maeso J, Ruf F, Bishop DF, Hof PR, Sealfon SC.
Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain.
Journal of Comparative Neurology 482:50-73 (2005)
González-Maeso J, Yuen T, Ebersole BJ, Wurmbach E, Lira A, Zhou M, Weisstaub N, Hen R, Gingrich JA, Sealfon SC.
Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex.
Journal of Neuroscience 23:8836-8843 (2003)
Wurmbach E, González-Maeso J, Yuen T, Ebersole BJ, Mastaitis JW, Mobbs CV, Sealfon SC.
Validated genomic approach to study differentially expressed genes in complex tissues.
Neurochemical Research 27:1027-1033 (2002)
González-Maeso J*, Wise A, Green A, Koenig JA.
Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cells.
Eurorean Journal of Pharmacology 481:15-23 (2003).
González-Maeso J, Torre I, Rodriguez-Puertas R, Garcia-Sevilla JA, Guimon J, Meana JJ.
Effects of age, postmortem delay and storage time on receptor-mediated activation of G-proteins in human brain.
Neuropsychopharmacology 26:468-478 (2002)
González-Maeso J*, Rodriguez-Puertas R, Meana JJ.
Quantitative stoichiometry of G-proteins activated by µ-opioid receptors in postmortem human brain.
European Journal of Pharmacology 452:21-33 (2002)
*corresponding author.
González-Maeso J, Rodriguez-Puertas R, Meana JJ, Garcia-Sevilla JA, Guimon J.
Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha2-adrenoceptors.
Molecular Psychiatry 7:755-767 (2002)
Irazusta J, Larrinaga G, González-Maeso J, Gil J, Meana JJ, Casis L.
Distribution of prolyl endopeptidase activities in rat and human brain.
Neurochemistry International 40:337-345 (2002)
Rodriguez-Puertas R, González-Maeso J, Meana JJ, Pazos A.
Autoradiography of receptor-activated G-proteins in post mortem human brain.
Neuroscience 96:169-180 (2000)
Meana JJ, González-Maeso J, Garcia-Sevilla JA, Guimon J. µ-opioid receptor and alpha2-adrenoceptor agonist stimulation of [35S]GTPgS binding to G-proteins in postmortem brains of opioid addicts. Molecular Psychiatry 5:308-315 (2000).
González-Maeso J, Rodriguez-Puertas R, Gabilondo AM, Meana JJ. Characterization of receptor-mediated [35S]GTPS binding to cortical membranes from postmortem human brain. European Journal of Pharmacology 390:25-36 (2000).
Gaitonde SA, Avet C, de la Fuente Revenga M, Blondel-Tepaz E, Shahraki A, Morales Pastor A, Talagayev V, Robledo P, Kolb P, Selent J, González-Maeso J, Bouvier M.
Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor
Molecular Psychiatry (Online ahead of print)
Zhu B^, Ainsworth RI^, Wang Z, Liu Z, Sierra S, Deng C, Callado LF, Meana JJ, Wang W*, Lu C*, González-Maeso J*
Antipsychotic-induced epigenomic reorganization in frontal cortex samples from individuals with schizophrenia.
eLife 12:RP92393 (2024)
- ^Equal contribution
- *co-corresponding authors
Takaba R, Ibi D, Yoshida K, Hosomi E, Kawase R, Kitagawa H, Goto H, Achiwa M, Mizutani K, Maede K, González-Maeso J, Hitagaki A, Hiramatsu M.
Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice.
Naunyn-Schmiedeberg's Archives of Pharmacology 397:3523 (2024)
2023
Jaster AM, González-Maeso J.
Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics.
Molecular Psychiatry 28:3595-3612 (2023)
- Expert review
Zhang Q, Ma S, Liu Z, Zhu B, Zhou Z, Li G, Meana JJ, González-Maeso J, Lu C.
Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes.
Nature Communications 14:4672 (2023)
Meana JJ, González-Maeso J.
Serotonin 5-HT2A receptors in schizophrenia: Reflexions on an unfinished story.
European Neuropsychopharmacology 74:89-91 (2023)
Saha S, González-Maeso J.
The crosstalk between 5-HT2AR and mGluR2 in schizophrenia.
Neuropharmacology 230:109489 (2023)
- Special Issue: The receptor-receptor interaction as a new target for therapy
2022
Wolstenholme J, Saunders JM, Smith M, Kang J, Hylemon P, González-Maeso J, Fagan A, Zhao D, Sikaroodi M, Herzog J, Shamsaddani A, Rodriguez M, Su L, Tai Y-L, Zheng J, Cheng B-C, Sartor R, Gillevet P, Zhou H, Bajaj J.
Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice.
Nature Communications 13:6198 (2022)
Saunders JM, Muguruza C, Sierra S, Moreno JL, Callado LF, Meana JJ, Beardsley PM, González-Maeso J.
Glucocorticoid receptor dysregulation underlies 5-HT2A receptor-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model.
Journal of Biological Chemistry 298:102481 (2022)
Jaster AM, Younkin J, Cuddy T, de la Fuente Revenga M, Poklis JL, Dozmorov MG, González-Maeso J.
Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice.
Neuroscience Letters 788:136836 (2022)
de la Fuente Revenga M, Jaster AM, McGinn J, Silva G, Saha S, González-Maeso J.
Tolerance and cross-tolerance among psychedelic and non-psychedelic 5-HT2A receptor agonists in mice.
ACS Chemical Neuroscience 13:2436-2448 (2022)
- Special Issue: DARK classics in chemical neuroscience
Meng J, Xu C, Lafon P-A, Roux S, Mathieu M, Zhou R, Scholler P, Blanc E, Becker J.A.J, Le Merrer J, González-Maeso J, Chames P, Liu J, Pin JP, Rondard P.
Optical biosensors of native membrane protein complexes reveal a high proportion of mGlu heterodimers in the brain.
Nature Chemical Biology 18:894-903 (2022)
Jaster AM, Elder H, Marsh SA, de la Fuente Revenga M, Negus SS*, González-Maeso J*
Effects of the 5-HT2A receptor antagonist volinanserin on head-twitch response and intracranial self-stimulation depression induced by different structural classes of psychedelics in rodents.
Psychopharmacology 239:1665-1667 (2022)
- *co-corresponding authors
- Special Issue: Psychopharmacology on Psychedelic Drugs
Sierra A, Muchhala KH, Jessup DK, Contreras KM, Shah UH, Stevens DL, Jimenez J, Cuno Lavilla XK, de la Fuente Revenga M, Lippold KM, Shen S, Poklis JL,, Qiao LY, Dewey WL, Akbarali HI, Damaj MI, González-Maeso J.
Sex-specific role for serotonin 5-HT2A receptor in modulation of opioid-induced antinociception and reward in mice.
Neuropharmacology 209:108988 (2022)
Jaster AM, González-Maeso J.
An upside-down binding mode to treat psychosis
Nature Neuroscience 25:4-6 (2022)
Jaster AM, de la Fuente Revenga, González-Maeso J.
Molecular targets of psychedelic-induced plasticity
Journal of Neurochemistry 162:(80-88 (2022)
- Special Issue: Psychedelics and Neurochemistry
- Top downloaded article during its first 12 months of publication
Ferre S, Ciruela F, Dessauer CW, González-Maeso J, Hebert TE, Jockers R, Logothetis DE, Pardo L.
G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs) as targets for drug discovery.
Pharmacology & Therapeutics 231:107977 (2022)
Vohra HZ, Saunders JM^, Jaster AM^, de la Fuente Revenga M, Jimenez J, Fernandez-Teruel A, Wolstenholme JT, Beardsley PM, González-Maeso J.
Sex-specific effects of psychedelics on prepulse inhibition of startle in 129S6/SvEv mice.
Psychopharmacology 239:1649-1664 (2022)
- ^Equal contribution
- Special Issue: Psychopharmacology on Psychedelic Drugs
2021
de la Fuente Revenga M, Zhu B^, Guevara CA^, Naler LB, Saunders JM, Zhou Z, Toneatti R, Sierra S, Wolstenholme JT, Beardsley PM, Huntley GW, Lu C*, González-Maeso J*
Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice.
Cell Reports 37:109836 (2021)
- Cover article
- ^Equal contribution
- *co-corresponding authors
- Treatments not trips. Nature 609:S80 (2022)
- Epigenetic roots of long-lasting therapy. Nature 609:S99 (2022)
Fernandez-Teruel A, Oliveras I, Cañete T, Rio-Alamos C, Tapias-Espinosa C, Sampedro-Viana D, Sanchez-Gonzalez A, Sanna F, Torrubia R, González-Maeso J, Driscoll P, Moron I, Torres C, Aznar S, Tobeña A, Corda MG, Giordi O.
Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia- and addiction-related features: The RHA vs. RLA rats.
Neuroscience & Biobehavioral Reviews 131:597-617 (2021)
Egusquiza I, Munarriz-Cuezva E, Segarra R, González-Maeso J, Callado LF, Meana JJ, Diez-Alarcia R.
Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia.
Pharmacological Reports 73:1136-1146 (2021)
- Special Issue: Role of G-proteins and GPCR-mediated signaling in the pathophysiology and treatment of psychiatric disorders
Zhang Y, Kang JD, Zhao D, Ghosh SS, Wang Y, Tai Y, González-Maeso J, Sikaroodi M, Guillevet PM, Lippman R, Hylemon PB, Zhou H, Bajaj J.
Hepatic branch vagotomy modulates the gut-liver-brain axis in murine cirrhosis.
Frontiers in Physiology 12:702646 (2021)
Martin-Guerrero SM, Alonso P, Iglesias A, Cimadevila M, Brea J, Loza MI, Casado P, Martin-Oliva D, Cutillas PR, González-Maeso J*, Lopez-Gimenez JF*.
His452Tyr Polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics.
Biochemical Pharmacology 185:114440 (2021)
- *co-corresponding authors
Sanchez-Gonzalez A, Thougaard E, Tapias-Espinosa C, Cañete T, Sampedro-Viana D, Saunders JM, Toneatti R, Tobeña A, González-Maeso J, Aznar S, Fernandez-Teruel A.
Increased thin-spine density in frontal cortex pyramidal neurons in a genetic rat model of schizophrenia-relevant features.
European Neuropsychopharmacology 44:79-91 (2021)
de la Fuente Revenga M^*, Shah U^, Nassehi N, Jaster A, Hemanth P, Sierra S, Dukat M, González-Maeso J*.
Psychedelic-like properties of quizapine and its structural analogs in mice.
ACS Chemical Neuroscience 12:831-844 (2021)
- ^Equal contribution
- *co-corresponding authors
- Special Issue: DARK classics in chemical neuroscience
2020
Toneatti R, Shin JM, Shah UH, Mayer CR, Saunders JM, Fribourg M, Arsenovic PT, Janssen WG, Sealfon SC, Lopez-Gimenez JF, Benson DL, Conway DE, González-Maeso J.
Interclass GPCR heteromerization affects localization and trafficking
Science Signaling 13, eaaw3122 (2020)
Shah UH, Toneatti R, Gaitonde SA, Shin JM, González-Maeso J.
Site-specific incorporation of genetically encoded photo-crosslinkers locates the heteromeric interface of a GPCR complex in living cells.
Cell Chemical Biology 27:1308-1317 (2020)
Ellaithy A, González-Maeso J, Logothetis DE, Levitz J.
Structure and function of class C G protein-coupled receptors
Trends in Biochemical Sciences 45:1049-1064 (2020)
Saunders JM, Moreno JL, Ibi D, Sikaroodi M, Kang DJ, Muñoz-Moreno R, Dalmet SS, Garcia-Sastre A, Gillevet PM, Dozmorov MG, Bajaj JS, González-Maeso J.
Gut microbiota manipulation during the prepubertal period shapes behavioral abnormalities in a mouse neurodevelopmental disorder model.
Scientific Reports 10:4697 (2020)
Sierra S, Kippold KM, Stevens DL, Poklis JL, Dewey WL, González-Maeso J.
Adjunctive effect of the 5-HT2C receptor agonist lorcaserin on opioid-induced antinociception in mice.
Neuropharmacology 167:107949 (2020)
- Special Issue: Serotonin Research - Crossing Scales and Boundaries.
de la Fuente Revenga M, Vohra HZ, González-Maeso J.
Automated quantification of head-twitch response in mice via ear tag reported coupled with biphasic detection
Journal of Neuroscience Methods 334:108595 (2020)
Osterbog TB, On DM, Oliveras I, Rio-Alamos C, Sanchez-Gonzalez A, Tapias-Espinosa C, Tobeña A, González-Maeso J, Fernandez-Teruel A, Aznar S.
Metabotropic glutamate 2 and dopamine receptor 2 gene expression predict sensorimotor gating response in the genetically heterogeneous NIH-HS rat strain.
Molecular Neurobiology 57:1516-1528 (2020)
Liu R, Kang JD, Balfour Sartor R, Sikaroodi M, Fagan A, Gavis E, Zhou H, Hylemon PB, Herzog JW, Li X, Lippman RH, González-Maeso J, Wade JB, Gosh S, Gurley E, Gillevet PM, Bajaj JS.
Neuroinflammation in murine cirrhosis is dependent on the gut microbiome and is attenuated by fecal transplant.
Hepatology 71:611-626 (2020)
2019
Garcia-Bea A, Miranda-Azpiazu P, Muguruza C, Marmolejo S, Diez-Alarcia R, Gabilondo AM, Callado LF, Morentin B, González-Maeso J, Meana JJ.
Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: selective biased agonism via Gi1-proteins.
European Neuropsychopharmacology 29:1453-1463 (2019)
Ruso-Julve F, Pombero A, Pilar-Cuellar F, Garcia-Diaz N, Garcia-Lopez R, Juncal-Ruiz M, Castro E, Diaz A, Vazquez-Bourgon J, Garcia-Blanco A, Garro-Martinez E, Pisonero H, Estirado A, Ayesa-Arriola R, Lopez-Gimenez JF, Mayor F Jr, Valizan E, Meana JJ, González-Maeso J, Martinez S, Vaque JP, Crespo-Facorro B.
Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK molecular effects of antipsychotics.
Translational Psychiatry 9:306 (2019)
Saunders JM, González-Maeso J, Bajaj JS.
The Toll of hyperammonemia on the Brain
Cellular and Molecular Gastroenterology and Hepatology 8:649-650 (2019)
de la Fuente Revenga M, Shin JM, Vohra HZ, Hideshima KS, Schneck M, Poklis JL, González-Maeso J.
Fully automated head-twitch detection system for the study of 5-HT2A receptor pharmacology in vivo.
Scientific Reports 9:14247 (2019)
Shah UH, González-Maeso J.
Serotonin and glutamate interactions in preclinical schizophrenia models
ACS Chemical Neuroscience 10:3068-3077 (2019)
- Special Issue: 2018 International Society for Serotonin Research Meeting.
Bajaj J, Sikaroodi M, Fagan A, Heuman D, Gilles HC, Gavis E, Fuchs M, González-Maeso J, Nizam S, Gillevet P, Wade J.
Post-traumatic stress disorder is associated with altered gut microbiota that modulates cognitive performance in veterans with cirrhosis.
American Journal of Physiology - Gastrointestinal and Liver Physiology 317:G661-G669 (2019).
Shah UH, Gaitonde SA, Moreno JL, Glennon RA, Dukat M, González-Maeso J.
Revised pharmacophore model for 5-HT2A receptor antagonists derived from the atypical antipsychotic agent risperidone.
ACS Chemical Neuroscience 10:2318-2331 (2019)
de la Fuente Revenga M, Ibi D, Cuddy T, Toneatti R, Kurita M, Ijaz MK, Ijaz MK, Miles MF, Wolstenholme JT, González-Maeso J.
Chronic clozapine treatment restrains via HDAC2 the performance of mGlu2 receptor agonism in a rodent model of antipsychotic activity.
Neuropsychopharmacology 44:443-454 (2019)
2018
Hideshima KS, Hojati A, Saunders JM, On DM, de la Fuente Revenga M, Shin JM, Sanchez-Gonzalez A, Dunn CM, Pais AB, Pais AC, Miles MF, Wolstenholme JT, González-Maeso J.
Role of mGlu2 in the 5-HT2A receptor-dependent antipsychotic activity of clozapine in mice.
Psychopharmacology 235:3149-3165 (2018)
Mato S, Pilar-Cuellar F, Valdizán EM, González-Maeso J, Rodríguez-Puertas R, Meana JJ, Salles J, Crespo-Facorro B, Pazos A.
Selective up-regulation of cannabinoid CB1 receptor coupling to Go-proteins in suicide victims with mood disorders.
Biochemical Pharmacology 157:258-265 (2018)
de la Fuente Revenga M, Ibi D, Saunders JM, Cuddy T, Ijaz MK, Toneatti R, Kurita M, Holloway T, Shen L, Seto J, Dozmorov MG, González-Maeso J.
HDAC2-dependent antipsychotic-like effects of chronic treatment with the HDAC inhibitor SAHA in mice.
Neuroscience 388:102-117 (2018)
Ma S, de la Fuente Revenga M, Sun Z, Sun C, Murphy TW, Xie H, González-Maeso J, Chang L.
Cell-type-specific brain methylomes profiled via ultralow-input microfluidics
Nature Biomedical Engineering 2:183-194 (2018)
- Comment by Feng-Mao Lin, Shu Chien and Zhen Chen in Nature Biomedical Engineering 2:147-148 (2018)
Mitchell AC, Javidfar B, Pothula V, Ibi D, Shen EY, Peter CJ, Bicks LK, Fehr T, Jiang Y, Brennand KJ, Neve RL, González-Maeso J, Akbarian S.
MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.
Molecular Psychiatry 23:123-132 (2018)
Fomsgaard L, Moreno JL, de la Fuente Revenga M, Brudek T, Adamsen D, Rio-Alamos C, Saunders J, Klein AB, Oliveras I, Cañete T, Blazquez G, Tobeña A, Fernandez-Teruel A, González-Maeso J, Aznar S.
Diferences in 5-HT2A and mGlu2 receptor expression levels and repressive epigenetic modifications at the 5-HT2A promoter region in the Roman Low- (RLA-I) and High (RLA-I) avoidance rat strains.
Molecular Neurobiology 55:1998-2012 (2018)
2017
Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, Garcia-Bea A, Kurita M, Mosley GE, Jiang Y, Christoffel DJ, Callado LF, Russo SJ, Dracheva S, Lopez-Gimenez JF, Ge Y, Escalante CR, Meana JJ, Akbarian S, Huntley GW, González-Maeso J.
Antipsychotic-induced Hdac2 transcription via NF-kB leads to synaptic and cognitive side effects.
Nature Neuroscience 20:1247-1259 (2017)
- Science Signaling Editors' Choice: Protecting cognition from antipsychotics (doi: 10.1126/scisignal.aap9121)
Fribourg M, Logothetis DE, González-Maeso J, Sealfon SC, Galocha-Iragüen B, Las-Heras Andres F, Brezina V.
Elucidation of molecular kinetic schemes from macroscopic traces using system identification.
PLoS Computational Biology 13(2):e1005376 (2017)
Lopez-Gimenez JF, de la Fuente Revenga M, Ruso-Julve F, Saunders JM, Moreno JL, Crespo-Facorro B, González-Maeso J.
Validation of schizophrenia gene expression profile in a preclinical model of maternal infection during pregnancy.
Schizophrenia Research 189:217-218 (2017)
Oliveras I, Sánchez-González A, Sampedro-Viana D, Piludu MA, Río-Alamos C, Giorgi O, Corda MG, Aznar S, González-Maeso J, Gerbolés C, Blázquez G, Cañete T, Tobeña A, Fernández-Teruel A.
Differential effects of antipsychotic and propsychotic drugs on prepulse inhibition and locomotor activity in Roman high- (RHA) and low-avoidance (RLA) rats.
Psychopharmacology 234:957-975 (2017)
2016
Holloway T, Moreno JL, González-Maeso J.
HSV-mediated transgene expression of chimeric constructs to study behavioral function of GPCR heteromers in mice.
The Journal of Visualized Experiments 113 (2016)
Younkin J, Gaitonde SA, Ellaithy A, Vekariya RH, Baki L, Moreno JL, Shah S, Drossopoulos P, Hideshima KS, Eltit JM, González-Maeso J, Logothetis DE, Dukak M, Glennon RA.
Reformulating a pharmacophore for 5-HT2A serotonin receptor antagonists.
ACS Chemical Neuroscience 7:1292-1299 (2016)
Gaitonde SA, González-Maeso J
Contribution of heteromerization to G protein-coupled receptor function.
Current Opinion in Pharmacology 32:23-31 (2016)
Baki L, Fribourg M, Younkin J, Eltit JM, Moreno JL, Park Gyu, Vysotskaya Z, Narahari A, Sealfon SC, González-Maeso J, Logothetis DE.
Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.
Pflügers Archiv - European Journal of Physiology 468:775-793 (2016)
Moreno JL, Miranda-Azpiazu P, Garcia-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Moron JA, Milligan G, Lopez-Gimenez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J.
Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
Science Signaling 9:ra5 (2016)
- Editor's summary: One to bind, one to signal
- Science Signaling Podcast: GPCR heteromers and schizophrenia
2015
Ellaithy A, Younkin J, González-Maeso J*, Logothetis DE*.
Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment.
Trends in Neurosciences 38:506-516 (2015)
- *co-corresponding authors
Holloway T, González-Maeso J.
Epigenetic mechanisms of serotonin signaling.
ACS Chemical Neuroscience 6:1099-1109 (2015)
- Special Issue: 2014 International Society for Serotonin Research Meeting.
Ibi D, González-Maeso J.
Epigenetic signaling in schizophrenia.
Cellular Signalling 27:2131-2136 (2015)
2014
Muguruza C, Miranda-Azpiazu P, Diez-Alarcia R, Morentin B, González-Maeso J, Callado LF, Meana JJ.
Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.
Neuropharmacology 86:311-318 (2014)
Gatch MB, Kozlenkov A, Huan RQ, Yang W, Nguyen JD, González-Maeso J, Rice KC, France CP, Dillon GH, Forster MJ, Schetz JA.
The HIV antiretroviral drug efavirenz has LSD-like properties.
Neuropsychopharmacology 38:2373-2384 (2013)
González-Maeso J.
Family A GPCR heteromers in animal models.
Frontiers in Pharmacology 5:226 (2014)
Hatcher-Solis C, Fribourg M, Spyridaki K, Younkin J, Ellaithy A, Xiang G, Liapakis G, González-Maeso J., Zhang H, Cui M, Logothetis DE. G protein coupled receptor signaling in Xenopus oocytes.
Current Pharmaceutical Biotechnology 15:987-995 (2014)
2013
Kurita M, Moreno JL, Holloway T, Kozlenkov A, Mocci G, Garcia-Bea A, Neve R, Nestler EJ, Russo SJ, González-Maeso J.
Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice.
Molecular Pharmacology 86:1166-1175 (2013)
- Among the top ten articles viewed by Molecular Pharmacology's readership
Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J.
Chronic treatment with LY341495 decreases 5-HT2A binding and hallucinogenic effects of LSD in mice.
Neuroscience Letters 536:69-73 (2013)
Golden SA, Christoffel DJ, Hodes GE, Heshmati M, Magida J, Davis K, Cahill ME, Dias C, Ribeiro E, Ables JL, Kennedy PJ, Robinson AJ, González-Maeso J, Neve RL, Turecki G, Ghose S, Tamminga CA, Russo SJ.
Epigenetic regulation of synaptic remodeling in stress disorders.
Nature Medicine 19:337-344 (2013)
Muguruza C, Moreno JL, Umali A, Callado LF, Meana JJ, González-Maeso J.
Dysregulated 5-HT2A receptor binding in postmortem frontal cortex of schizophrenic subjects.
European Neuropsychopharmacology 23:852-864 (2013)
Holloway T, Moreno JL, Umali A, Rayannavar V, Hodes GE, Russo SJ, González-Maeso J.
Prenatal stress induces schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring: Role of maternal immune system.
Journal of Neuroscience 33:1088-1098 (2013).
Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J.
Long-lasting effects of chronic clozapine on the psychosis-like states induced by LSD in mice.
Psychopharmacology 225:217-226 (2013).
Hanks JB, González-Maeso J.
Animal models of serotonergic psychedelics.
ACS Chemical Neuroscience 4:33-42 (2013)
- Special Issue: Celebrating 25 years of the serotonin club.
Moreno JL, González-Maeso J.
Preclinical models of antipsychotic drug action.
The International Journal of Neuropsychopharmacology 16:2131-2144 (2013)
- Special Section: Preclinical models of schizophrenia.
Kurita M, Holloway T, González-Maeso J.
HDAC2 as a new target to improve schizophrenia treatment.
Expert Review of Neurotherapeutics 13:1-3 (2013)
2012
Williams A, Ingram WM, Levine S, Resnik J, Kamel C, Lish JR, Elizalde DI, Janowski SA, Shoker J, Kozlenkov A, González-Maeso J, Gallitano AL.
Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine.
Neuropsychopharmacology 37:2285-2298 (2012)
Kurita M, Holloway T, Garcia-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden S, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J.
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Nature Neuroscience 15:1245-1254 (2012)
- Cover article
- Comment by Steven E. Hyman in Nature Neuroscience 15:1180-1181 (2012)
- Research Highlights in Nature Reviews Neuroscience (doi: 10.1038/nrn3333)
- Research Highlights in Nature Medicine (doi: 10.1038/nm2950)
- Comments on The Scientist, Psychiatric News, and Medscape, among others.
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuellar F, Mocci G, Hanks J, Seto J, Callado LF, Milligan G, Sealfon SC, Lopez-Gimenez JF, Meana JJ, Benson DL, González-Maeso J.
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A-mGlu2) receptor heteromerization and its psychoactive behavioral function.
Journal of Biological Chemistry 287:44301-44319 (2012)
González-Maeso J, Sealfon SC.
Functional selectivity in GPCR heterocomplexes.
Mini-Reviews in Medicinal Chemistry 12:851-855 (2012)
2011
Albizu L, Holloway T, González-Maeso J, Sealfon SC.
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors.
Neuropharmacology 61:770-777 (2011)
Moreno JL, Holloway T, Albizu L, Sealfon, SC, González-Maeso J.
Metabotropic glutamate receptor mGlu2 is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonist.
Neuroscience Letters 493:76-79 (2011)
Moreno JL, Kurita M, Holloway T, Lopez J, Cadagan R, Martinez-Sobrido L. Garcia-Sastre A, González-Maeso J.
Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors complex in the adult offspring.
Journal of Neuroscience 31:1863-1872 (2011).
- Cover article
- This week in the journal article: Journal of Neuroscience 31:i-i (2011).
- Evaluated by Faculty of 1000 Biology: http://f1000.com/prime/8251956
Fribourg M, Moreno, JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerrell AD, Brezina V, Sealfon SC, Filizola M, González-Maeso J*, Logothetis DE*.
Decoding the signaling of a GPCR heteromeric complex reveals the mechanism of action of antipsychotic drugs.
Cell 147:1011-1023 (2011)
- *co-corresponding authors
- Cover article
- Comment by Mari Kondo and Akira Sawa in Cell 147:946-965 (2011)
- Research Highlights in Nature Genetics (doi: 10.1038/ng.1063)
- Science Signaling Editors' Choice: How to design a better antipsychotic (doi: 10.1126/scisignal.4202ec342)
- Evaluated by Faculty of 1000 Biology: http://f1000.com/prime/13409956
González-Maeso J.
GPCR oligomers in pharmacology and signaling.
Molecular Brain 4:20-26 (2011)
2010
Valdizan EM, Diez-Alarcia R, González-Maeso J, Pilar-Cuellar F, Garcia-Sevilla J, Meana JJ, Pazos A.
Alpha2-adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims.
Biological Psychiatry 68:869-872 (2010)
Albizu L, Moreno JL, González-Maeso J, Sealfon SC.
G protein-coupled receptor heterodimers and novel drug targets.
CNS & Neurological Disorders—Drug Targets 9:636-650 (2010)
González-Maeso J. Anxious interactions.
Nature Neuroscience 13:524-526 (2010)
2009
Moreno JL, Sealfon SC, González-Maeso J.
Group II metabotropic glutamate receptors and schizophrenia.
Cellular and Molecular Life Sciences 66:3777-3785 (2009)
González-Maeso J, Sealfon SC. Psychedelics and schizophrenia.
Trends in Neurosciences 32:225-232 (2009)
González-Maeso J, Sealfon SC.
Agonist-signaling trafficking and hallucinogens.
Current Medicinal Chemistry 16:1017-1027 (2009)
2008 and before
González-Maeso J*, Ang R, Yuen T, Chan P, Weisstaub NV, Lopez-Gimenez J, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Meana JJ, Sealfon SC*.
Identification of a glutamate/serotonin receptor complex implicated in psychosis. Nature 452:93-97 (2008)
- *co-corresponding authors
- Comment by Solomon H. Snyder in Nature 452:38-39 (2008)
- Evaluated by Faculty of 1000 Biology: http://f1000.com/prime/1103365
- Research Highlights in Nature Clinical Practice Neurology 4:292 (2008)
- Research Highlights in Nature Medicine (doi: 10.1038/nm0308-252)
- Research Highlights in Nature Reviews Drug Discovery (doi: 10.1038/nrd2555)
- Research Highlights in Nature Reviews Neuroscience (doi: 10.1038/nrn2362)
Sealfon SC, González-Maeso J.
Receptor pair for schizophrenia.
Pediatric Research 64:1 (2008)
González-Maeso J*, Weisstaub NV*, Zhou M, Lira A, Bradley-Moore M, Chan P, Ivic L, Ge Y, Zhou Q, Sealfon SC, and Gingrich JA.
Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior.
Neuron 53:439-452 (2007)
- *Equal contribution
- Comments on Scientific American, CBS News, Washington Post, and ABC, among others.
González-Maeso J, Meana JJ.
Heterotrimeric G proteins: Insights into the Neurobiology of Mood Disorders.
Current Neuropharmacology 4:127-138 (2006)
Nair VD, McNaught, KP, González-Maeso J, Sealfon SC, Olanow CW.
p53 Mediates non-transcriptional mediated cell death in dopaminergic cells in response to proteasome inhibition.
Journal of Biological Chemistry 281:39550-39560 (2006)
Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA.
Cortical 5-HT2A receptor signaling specifically modulates anxiety-related behaviors in mice.
Science 313:536-540 (2006)
Chan P, Yuen T, Ruf F, González-Maeso J, Sealfon SC.
Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization.
Nucleic Acid Research 33:e161 (2005)
Chan P, González-Maeso J, Ruf F, Bishop DF, Hof PR, Sealfon SC.
Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain.
Journal of Comparative Neurology 482:50-73 (2005)
González-Maeso J, Yuen T, Ebersole BJ, Wurmbach E, Lira A, Zhou M, Weisstaub N, Hen R, Gingrich JA, Sealfon SC.
Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex.
Journal of Neuroscience 23:8836-8843 (2003)
Wurmbach E, González-Maeso J, Yuen T, Ebersole BJ, Mastaitis JW, Mobbs CV, Sealfon SC.
Validated genomic approach to study differentially expressed genes in complex tissues.
Neurochemical Research 27:1027-1033 (2002)
González-Maeso J*, Wise A, Green A, Koenig JA.
Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cells.
Eurorean Journal of Pharmacology 481:15-23 (2003).
- *corresponding author.
González-Maeso J, Torre I, Rodriguez-Puertas R, Garcia-Sevilla JA, Guimon J, Meana JJ.
Effects of age, postmortem delay and storage time on receptor-mediated activation of G-proteins in human brain.
Neuropsychopharmacology 26:468-478 (2002)
González-Maeso J*, Rodriguez-Puertas R, Meana JJ.
Quantitative stoichiometry of G-proteins activated by µ-opioid receptors in postmortem human brain.
European Journal of Pharmacology 452:21-33 (2002)
*corresponding author.
González-Maeso J, Rodriguez-Puertas R, Meana JJ, Garcia-Sevilla JA, Guimon J.
Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha2-adrenoceptors.
Molecular Psychiatry 7:755-767 (2002)
Irazusta J, Larrinaga G, González-Maeso J, Gil J, Meana JJ, Casis L.
Distribution of prolyl endopeptidase activities in rat and human brain.
Neurochemistry International 40:337-345 (2002)
Rodriguez-Puertas R, González-Maeso J, Meana JJ, Pazos A.
Autoradiography of receptor-activated G-proteins in post mortem human brain.
Neuroscience 96:169-180 (2000)
Meana JJ, González-Maeso J, Garcia-Sevilla JA, Guimon J. µ-opioid receptor and alpha2-adrenoceptor agonist stimulation of [35S]GTPgS binding to G-proteins in postmortem brains of opioid addicts. Molecular Psychiatry 5:308-315 (2000).
González-Maeso J, Rodriguez-Puertas R, Gabilondo AM, Meana JJ. Characterization of receptor-mediated [35S]GTPS binding to cortical membranes from postmortem human brain. European Journal of Pharmacology 390:25-36 (2000).
- ^Equal contribution
- *co-corresponding author
Book chapters:
Jaster AM, González-Maeso J.
Automated detection of psychedelic-induced head twitch response in mice
In: Schizophrenia: Methods and Protocols - Methods in Molecular Biology
Edited by Leyre Urigüen and Rebeca Diaz-Alarcia
Springer (2023)
ISBN: 978-1-0716-3306-9
Sierra S, Toneatti R, González-Maeso J.
Class A GPCR oligomerization: Reasons of controversy.
In: GPCRs: Structure, Function and Drug Discovery
Edited by Beata Jastrzebska and Paul S.-H. Park
Elsevier (2020)
ISBN: 978-0-12-816228-6
Shah U, Pincas H, Sealfon SC, González-Maeso J.
Structure and function of serotonin GPCR heteromers.
In: Handbook of the Behavioral Neurobiology of Serotonin (second edition)
Edited by Christian Müller and Kathryn Cunningham
Elsevier (2020)
ISBN: 978-0-444-64125-0
Moreno JL, González-Maeso J.
Crosstalk between 5-HT2A and mGlu2 receptors: Implications in schizophrenia and its treatment.
In: 5-HT2A receptors in the Central Nervous System
Edited by Bruno P. Guiard, Giuseppe Di Giovanni
Springer (2018)
ISBN: 978-3-319-70472-2
González-Maeso J.
Metabotropic Glutamate 2 (mGlu2) Receptors and Schizophrenia Treatment.
In: mGlu Receptors.
Edited by Richard Take Ngomba, Giuseppe Di Giovanni, Giuseppe Battaglia, Ferdinando Nicoletti
Humana Press (2017)
ISBN: 978-3-319-56168-4
Pincas H, González-Maeso J, Ruf-Zamojski F, Sealfon SC.
G Protein-Coupled Receptors.
In: Principles of Endocrinology and Hormone Action.
Edited by Antonino Belfiore and Derek LeRoith
Springer (2017)
ISBN: 978-3-319-44674-5
López-Giménez, González-Maeso J.
Hallucinogens and serotonin 5-HT2A receptor-mediated signaling.
In: Behavioral Neurobiology of Psychedelic Drugs.
Edited by Adam L. Halberstadt, Franz X. Vollenweider, David E. Nichols.
Springer (2017)
ISBN: 978-3662558782
Hanks JB, González-Maeso J.
Hallucinogens: Circuits, behavior and translational models.
In: The Neuropathology of drug addiction and substance misuse.
Edited by Victor R. Preedy.
Elsevier (2016)
ISBN: 9780128006771
Hanks JB, González-Maeso J.
Molecular and cellular basis of hallucinogenic drug action.
In: The Neuropathology of drug addiction and substance misuse.
Edited by Victor R. Preedy.
Elsevier (2016)
ISBN: 9780128006771
Kurita M, Garcia-Bea A, González-Maeso J.
Novel targets for Drug Treatment in Psychiatry.
In: The Medical Basis of Psychiatry (Fourth Edition).
Edited by S. Hossein Fatemi and Paula J. Clayton.
Humana Press (2015)
ISBN: 978-1-4939-2527-8
Moreno J, Seto J, Hanks JB, González-Maeso J.
Techniques to the study of GPCR heteromerization in living cells and animal models.
In: Neuromethods (Serotonin receptor technologies).
Edited by Wolfgang Blenau and Arnd Baumann.
Springer (2015)
ISBN: 978-1-4939-2187-4
Moreno JL, Holloway T, González-Maeso J.
G protein-coupled receptor heterocomplexes in neuropsychiatric disorders.
In: Progress in Molecular Biology and Translational Science (Oligomerization in Health and Disease).
Edited by Jesus Giraldo and Francisco Ciruela.
Elsevier (2013)
ISBN: 978-0-12-386931-9
Kozlenkov A, González-Maeso J.
Animal models and hallucinogenic drugs.
In: The Neuroscience of Hallucinations.
Edited by Renaud Jardri, Arnaud Cachia, Pierre Thomas and Delphine Pins.
Springer (2012)
ISBN: 978-1-4614-4120-5
Lopez-Gimenez J, González-Maeso J.
Oligomerization of G protein coupled-receptors.
In: Therapeutic Targets: Modulation, Inhibition, and Activation.
Edited by Luis M. Botana and Mabel Loza.
John Wiley & Sons (2012)
ISBN: 978-0470587195
González-Maeso J, and Sealfon S.C.
Hormone Signaling via G-protein coupled receptors.
In: Endocrinology 6th Edition.
Edited by J. Larry Jameson and Leslie J. De Groot.
Elsevier (2010)
ISBN: 978-1-4160-5583-9
González-Maeso J, Sealfon SC.
Hormone Signaling via G-protein coupled receptors.
In: Endocrinology 5th Edition.
Edited by J. Larry Jameson and Leslie J. De Groot.
Elsevier (2006)
ISBN: 0721603769
González-Maeso J, Sealfon SC.
Structure of G-protein coupled receptors.
In: Encyclopedia of Hormones.
Edited by Henry H and Anthony W Norman.
Academic Press (2003)
ISBN: 978-0123411037
Automated detection of psychedelic-induced head twitch response in mice
In: Schizophrenia: Methods and Protocols - Methods in Molecular Biology
Edited by Leyre Urigüen and Rebeca Diaz-Alarcia
Springer (2023)
ISBN: 978-1-0716-3306-9
Sierra S, Toneatti R, González-Maeso J.
Class A GPCR oligomerization: Reasons of controversy.
In: GPCRs: Structure, Function and Drug Discovery
Edited by Beata Jastrzebska and Paul S.-H. Park
Elsevier (2020)
ISBN: 978-0-12-816228-6
Shah U, Pincas H, Sealfon SC, González-Maeso J.
Structure and function of serotonin GPCR heteromers.
In: Handbook of the Behavioral Neurobiology of Serotonin (second edition)
Edited by Christian Müller and Kathryn Cunningham
Elsevier (2020)
ISBN: 978-0-444-64125-0
Moreno JL, González-Maeso J.
Crosstalk between 5-HT2A and mGlu2 receptors: Implications in schizophrenia and its treatment.
In: 5-HT2A receptors in the Central Nervous System
Edited by Bruno P. Guiard, Giuseppe Di Giovanni
Springer (2018)
ISBN: 978-3-319-70472-2
González-Maeso J.
Metabotropic Glutamate 2 (mGlu2) Receptors and Schizophrenia Treatment.
In: mGlu Receptors.
Edited by Richard Take Ngomba, Giuseppe Di Giovanni, Giuseppe Battaglia, Ferdinando Nicoletti
Humana Press (2017)
ISBN: 978-3-319-56168-4
Pincas H, González-Maeso J, Ruf-Zamojski F, Sealfon SC.
G Protein-Coupled Receptors.
In: Principles of Endocrinology and Hormone Action.
Edited by Antonino Belfiore and Derek LeRoith
Springer (2017)
ISBN: 978-3-319-44674-5
López-Giménez, González-Maeso J.
Hallucinogens and serotonin 5-HT2A receptor-mediated signaling.
In: Behavioral Neurobiology of Psychedelic Drugs.
Edited by Adam L. Halberstadt, Franz X. Vollenweider, David E. Nichols.
Springer (2017)
ISBN: 978-3662558782
Hanks JB, González-Maeso J.
Hallucinogens: Circuits, behavior and translational models.
In: The Neuropathology of drug addiction and substance misuse.
Edited by Victor R. Preedy.
Elsevier (2016)
ISBN: 9780128006771
Hanks JB, González-Maeso J.
Molecular and cellular basis of hallucinogenic drug action.
In: The Neuropathology of drug addiction and substance misuse.
Edited by Victor R. Preedy.
Elsevier (2016)
ISBN: 9780128006771
Kurita M, Garcia-Bea A, González-Maeso J.
Novel targets for Drug Treatment in Psychiatry.
In: The Medical Basis of Psychiatry (Fourth Edition).
Edited by S. Hossein Fatemi and Paula J. Clayton.
Humana Press (2015)
ISBN: 978-1-4939-2527-8
Moreno J, Seto J, Hanks JB, González-Maeso J.
Techniques to the study of GPCR heteromerization in living cells and animal models.
In: Neuromethods (Serotonin receptor technologies).
Edited by Wolfgang Blenau and Arnd Baumann.
Springer (2015)
ISBN: 978-1-4939-2187-4
Moreno JL, Holloway T, González-Maeso J.
G protein-coupled receptor heterocomplexes in neuropsychiatric disorders.
In: Progress in Molecular Biology and Translational Science (Oligomerization in Health and Disease).
Edited by Jesus Giraldo and Francisco Ciruela.
Elsevier (2013)
ISBN: 978-0-12-386931-9
Kozlenkov A, González-Maeso J.
Animal models and hallucinogenic drugs.
In: The Neuroscience of Hallucinations.
Edited by Renaud Jardri, Arnaud Cachia, Pierre Thomas and Delphine Pins.
Springer (2012)
ISBN: 978-1-4614-4120-5
Lopez-Gimenez J, González-Maeso J.
Oligomerization of G protein coupled-receptors.
In: Therapeutic Targets: Modulation, Inhibition, and Activation.
Edited by Luis M. Botana and Mabel Loza.
John Wiley & Sons (2012)
ISBN: 978-0470587195
González-Maeso J, and Sealfon S.C.
Hormone Signaling via G-protein coupled receptors.
In: Endocrinology 6th Edition.
Edited by J. Larry Jameson and Leslie J. De Groot.
Elsevier (2010)
ISBN: 978-1-4160-5583-9
González-Maeso J, Sealfon SC.
Hormone Signaling via G-protein coupled receptors.
In: Endocrinology 5th Edition.
Edited by J. Larry Jameson and Leslie J. De Groot.
Elsevier (2006)
ISBN: 0721603769
González-Maeso J, Sealfon SC.
Structure of G-protein coupled receptors.
In: Encyclopedia of Hormones.
Edited by Henry H and Anthony W Norman.
Academic Press (2003)
ISBN: 978-0123411037
Articles and Book Chapters in Spanish
(Artículos y Capítulos de Libro en Castellano)
González-Maeso J.
Arquitectos de la comunicación celular.
Investigación y Ciencia — Scientific American 474:54-62 (2016)
Fribourg M, Moreno JL, González-Maeso J.
Baremo para los fármacos antipsicóticos.
Mente y Cerebro (Investigación y Ciencia — Scientific American) 68:18-19 (2014)
Meana JJ, Miranda-Azpiazu P, Muguruza C, Diez-Alarcia R, Callado LF, González-Maeso J.
Diferentes propiedades farmacológicas de ketanserina y altanserina sobre los receptores 5-HT2A en cerebro humano postmortem: Interés en estudio de esquizofrenia.
Actualidad en Farmacología y Terapéutica 12:59-63 (2014)
Moreno JL, Fribourg M, González-Maeso J.
Bases bioquímicas de la esquizofrenia.
Mente y Cerebro (Investigación y Ciencia — Scientific American) 44:18-27 (2010)
González-Maeso J, Meana JJ.
Implicación de los adrenoceptores alfa 2 en depresión endógena y transtorno bipolar.
Avances neurocientíficos y realidad clínica: El espectro bipolar.
Eds. Palomo T., Beninger R.J., Jimenez-Arriero M.A. and Huertas E.
Fundación Cerebro y Mente (2002)
ISBN: 84-921848-7-6
González-Maeso J, Rodríguez-Puertas R, Meana JJ, García-Sevilla JA, Guimón J.
Actividad functional de los adrenoceptores alfa 2 en cerebro postmortem de sujetos suicidas con depresión y transtorno bipolar.
Diagnóstico diferencial y racionalización del tratamiento psicofarmacológico.
Ed. Pichot P.
Aula Médica Ediciones (2001)
ISBN: 84-7885-264-6
Arquitectos de la comunicación celular.
Investigación y Ciencia — Scientific American 474:54-62 (2016)
Fribourg M, Moreno JL, González-Maeso J.
Baremo para los fármacos antipsicóticos.
Mente y Cerebro (Investigación y Ciencia — Scientific American) 68:18-19 (2014)
Meana JJ, Miranda-Azpiazu P, Muguruza C, Diez-Alarcia R, Callado LF, González-Maeso J.
Diferentes propiedades farmacológicas de ketanserina y altanserina sobre los receptores 5-HT2A en cerebro humano postmortem: Interés en estudio de esquizofrenia.
Actualidad en Farmacología y Terapéutica 12:59-63 (2014)
Moreno JL, Fribourg M, González-Maeso J.
Bases bioquímicas de la esquizofrenia.
Mente y Cerebro (Investigación y Ciencia — Scientific American) 44:18-27 (2010)
- Chosen as one of the best 10 articles of the last 10 years.
- Translated to Italian (Mente & Cervello) and German (Gehirn und Geist).
González-Maeso J, Meana JJ.
Implicación de los adrenoceptores alfa 2 en depresión endógena y transtorno bipolar.
Avances neurocientíficos y realidad clínica: El espectro bipolar.
Eds. Palomo T., Beninger R.J., Jimenez-Arriero M.A. and Huertas E.
Fundación Cerebro y Mente (2002)
ISBN: 84-921848-7-6
González-Maeso J, Rodríguez-Puertas R, Meana JJ, García-Sevilla JA, Guimón J.
Actividad functional de los adrenoceptores alfa 2 en cerebro postmortem de sujetos suicidas con depresión y transtorno bipolar.
Diagnóstico diferencial y racionalización del tratamiento psicofarmacológico.
Ed. Pichot P.
Aula Médica Ediciones (2001)
ISBN: 84-7885-264-6